Proliferating activity and differentiation between peripheral cells and central cells in ameloblastoma.
- Author:
Jinzhong LIU
1
;
Shuozhi WANG
;
Xinming CHEN
;
Yuan LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Ameloblastoma; chemistry; pathology; Cell Differentiation; Cell Division; Child; Female; Humans; Jaw Neoplasms; chemistry; pathology; Keratins; analysis; Ki-67 Antigen; analysis; Male; Middle Aged; Proliferating Cell Nuclear Antigen; analysis
- From: Chinese Journal of Stomatology 2002;37(1):62-64
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the proliferating activities and differentiation between peripheral cells and central cells in ameloblastoma.
METHODSExpressions of proliferating cell nuclear antigen (PCNA), Ki-67, CK10&13 and CK19 were detected in 43 ameloblastoma (15 follicular, 20 plexiform and 8 acanthomatous) by SP immunohistochemical methods.
RESULTSThe PCNA labelling indices were significantly higher in peripheral cells (5.12% +/- 2.76%) of tumour nests or strands than in central cells (1.36% +/- 1.02%, P < 0.001). The peripheral cells of tumour nests or strands exhibited a significantly higher Ki-67 labelling index (3.63% +/- 1.80%) than central cells (1.26% +/- 0.96%, P < 0.001). The labelling indices between PCNA and Ki-67 showed a significant correlation (P < 0.01). The positive expressions of CK10&13 and CK19 were significantly higher in central cells than in peripheral cells (P < 0.01).
CONCLUSIONSThe peripheral zones of tumour nests or strands are regarded as proliferating areas; there exists a significantly different differentiation between central cells and peripheral cells.
