Expression of epidermal growth factor and epidermal growth factor receptor in rat periodontal tissues during orthodontic tooth movement.
- Author:
Qingping GAO
1
;
Suyin ZHANG
;
Xinchun JIAN
;
Qingfu ZENG
;
Lifeng REN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; EGF Family of Proteins; Molar; Periodontal Ligament; metabolism; Periodontium; metabolism; Rats; Receptor, Epidermal Growth Factor; Tooth Movement Techniques
- From: Chinese Journal of Stomatology 2002;37(4):294-296
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo detect the expression and distribution of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in periodontal tissues, and analyze the role of EGF in orthodontic tooth movement.
METHODSAccording to Kings methods, 40 g mesial force was applied to pull the left maxillary first molar in the rat. Using immunohistochemical method (HI-SABC method) to localize and examine the expression of EGF and EGFR in decalcified alveodental connective tissues at 24 hours and 168 hours of tooth movement.
RESULTSEGF and EGFR were stained at some of periodontal ligament of furcation and radical regions in control group. These expressions of EGF and EGFR increased in periodontal tissues (P < 0.01), with the expressions at 168 hours higher than those at 24 hours (P < 0.01). And levels of EGF and EGFR at tension side were higher than those at pressure side at the same time (P < 0.01).
CONCLUSIONSEpidermal growth factor participated in the tissues remodeling during orthodontic tooth movement and especially played a more important role in orthodontic bone formation.
