A study of the ultrastructure and gene location of hereditary gingival fibromatosis.
- Author:
Minghua YANG
1
;
Dongsheng ZHANG
;
Shangxi XIAO
;
Xiaofeng HUANG
;
Jilie ZHENG
;
Xiangyin KONG
Author Information
- Publication Type:Case Reports
- MeSH: Child; Chromosome Mapping; Chromosomes, Human, Pair 5; genetics; Family Health; Female; Fibromatosis, Gingival; genetics; pathology; ultrastructure; Genetic Predisposition to Disease; genetics; Gingiva; metabolism; pathology; ultrastructure; Humans; Male; Microsatellite Repeats; Microscopy, Electron; Pedigree
- From: Chinese Journal of Stomatology 2002;37(3):170-172
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo ascertain histology changes of hereditary gingival fibromatosis (HGF) and the location of HGF gene.
METHODSA pedigree analyses of HGF; and the ultrastructure of gingival overgrowth tissue was observed with electron microscopy. The overgrowth of the HGF gene was defined with microsatellite markers.
RESULTSThe connective tissue of HGF consisted of coarse collagen bundles and several kinds of cells arranged abnormally, such as: epithelial cells, smooth muscle cells and so on; the HGF locus had been mapped to chromosome 5q13-q22.
CONCLUSIONSThe gingival pathologic changes resemble "hamartoma"; the findings has implications for identification of the underlying genetic basis of HGF.
