The changes of cytokeratin 19 during oral carcinogenesis.
- Author:
Minhai NIE
1
;
Li ZHONG
;
Guangming ZENG
;
Bingqi LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Blotting, Western; Female; Humans; Immunohistochemistry; Keratins; analysis; Male; Middle Aged; Mouth Mucosa; metabolism; pathology; Mouth Neoplasms; metabolism; pathology; Precancerous Conditions; metabolism; pathology
- From: Chinese Journal of Stomatology 2002;37(3):187-190
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the changes of cytokeratin 19 during oral carcinogenesis.
METHODS53 specimens including normal oral mucosa, oral epithelial hyperplasia, oral epithelial dysplasia and oral squamous cell carcinoma were investigated by immunohistochemistry, SDS-PAGE and Western blotting.
RESULTSCK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor-differentiated cancerous cells. With the lesions getting worse, the positive rate, the intensity and the constituent ratio of CK19 raised significantly.
CONCLUSIONSThe results suggest that the CK19 expression in suprabasal cell layers of oral mucosa can be used as a marker of diagnosis of oral precancerous lesions and CK19 expression is the initial events during oral carcinogenesis.
