Correlation between levels of n-terminal pro-b-type natriuretic peptide and degrees of heart failure.
- Author:
Bong Geun SONG
1
;
Eun Seok JEON
;
Yong Hoon KIM
;
Min Kyung KANG
;
Joon Hyung DOH
;
Phil Ho KIM
;
Seok Jin AHN
;
Hye Lim OH
;
Hyun Joong KIM
;
Ji Dong SUNG
;
Sang Chol LEE
;
Hyeon Cheol GWON
;
June Soo KIM
;
Duk Kyung KIM
;
Sang Hoon LEE
;
Kyung Pyo HONG
;
Jeong Euy PARK
;
Soo Youn LEE
;
Jong Koo LEE
Author Information
1. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Cardiac and Vascular Center, Seoul, Korea. esjeon@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Natriuretic peptides;
Heart failure;
Myocardial ischemia
- MeSH:
Cardiology;
Dyspnea;
Echocardiography;
Heart Failure*;
Heart Ventricles;
Heart*;
Humans;
Myocardial Ischemia;
Natriuretic Peptide, Brain;
Natriuretic Peptides;
ROC Curve
- From:Korean Journal of Medicine
2004;66(1):33-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: N-terminal fragment of pro Brain Natriuretic Peptide (NT-pro BNP) is a neuro-hormone synthesized from the cardiac ventricles in response to increased wall tension. The purpose of this study was to assess the correlation between NT-pro BNP levels and New York Heart Association function class (NYHA Fc) and echocardiographic findings in patients, who visited cardiology department. METHODS: From October, 2002 to April, 2003, serum NT-pro BNP levels were measured in 348 patients, who visited Samsung Medical Center and Jong Koo Lee Heart Clinic. RESULTS: NT-pro BNP levels were increased with the progression of NYHA Fc of dyspnea (p<0.001 by ANOVA) as well as with the increase in systolic left ventricular internal dimension (p<0.05) and the decrease in ejection fraction (p<0.01). In NYHA Fc I patients, NT-pro BNP levels were positively correlated with age (p<0.001) and left atrial size (p<0.001). In patients with ischemic heart disease, NT-pro BNP levels were also positively correlated with NYHA Fc (p<0.001 by ANOVA). NT-pro BNP levels were increased with the increase in systolic (p<0.001) and diastolic (p=0.017) left ventricular internal dimension as well as the decrease in ejection fraction (p<0.001). The area under the receiver operating characteristic (ROC) curve for NT-pro BNP levels was 0.994 (95% confidence interval, 0.979-0.999), and the most reliable cut-off level of NT-pro BNP was 293.6 pg/mL. CONCLUSION: NT-pro BNP levels were positively correlated with NYHA Fc of dyspnea and systolic dysfunction in patients, who visited cardiology department. A 300 pg/mL of NT-pro BNP level appears to be a sensitive level to differentiate dyspnea of heart origin or not in patients, who visited cardiology department.
