Study on the swelling and release properties of pectinate gel beads crosslinked with different metal ions.
- Author:
Liangke ZHANG
1
;
Pei YUAN
;
Rui TIAN
;
Xu LING
;
Ruijie YU
Author Information
1. Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China. zlkdyx@sina.com
- Publication Type:Journal Article
- MeSH:
Calcium;
chemistry;
pharmacology;
Cross-Linking Reagents;
Delayed-Action Preparations;
Drug Carriers;
chemistry;
Ferric Compounds;
chemistry;
pharmacology;
Gels;
chemistry;
Metals;
chemistry;
pharmacology;
Microspheres;
Pectins;
chemistry
- From:
Journal of Biomedical Engineering
2009;26(5):1030-1033
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to reveal how the swelling properties and release behavior of a model drug from pectin gel beads were influenced by its crosslinking with different metal ions. Coomassie Brilliant Blue G-250 was chosen as the model drug. Pectinate beads were prepared by the dropping method and crosslinked with Ca2+, Fe3+, Zn2+, Ba2+, respectively. The release behavior and swelling properties were investigated. The results showed that there were significant differences between the pectinate beads that were crosslinked with different ions. Pectinate gel beads, as a potential cell microencapsulation and drug vehicle, could be acquired for different release profile by crosslinking with different ions.
