On the preparation of an amphiphilic cholesterol adsorbent and its adsorption properties.
- Author:
Hui ZHAO
1
;
Bo FANG
;
Jingjing CHEN
;
Wei LIU
;
Lirong LIU
;
Ruirui WANG
Author Information
1. Research Center of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China.
- Publication Type:Journal Article
- MeSH:
Adsorption;
Biocompatible Materials;
chemistry;
Blood Component Removal;
instrumentation;
methods;
Cholesterol;
isolation & purification;
Dietary Fiber;
pharmacology;
Lipoproteins, LDL;
isolation & purification;
Surface-Active Agents;
chemical synthesis;
chemistry
- From:
Journal of Biomedical Engineering
2009;26(5):1039-1042
- CountryChina
- Language:Chinese
-
Abstract:
An amphiphilic LDL adsorbent was synthesized with dietary fiber as the carrier, laurylamine as hydrophobic group and 3-Chloro-2-hydroxylpropysodium sulfonate as sulphonation reagent. The effects of reaction time, reaction temperature and amount of 3-Chloro-2-hydroxylpropysodium sulfonate on SO4(2-) content were studied, and the required preparations were made. The condition for adsorption was obtained by investigating the influence of adsorbent amount and adsorption time. The results show that the adsorption percentages for the removal of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) are 49.6%, 60.0% and 18.2%, respectively. This amphiphilic adsorbent possesses a better selectivity in removing cholesterol.
