A five-element lumped-parameter model for cerebral blood flow autoregulation.
- Author:
Shengzhang WANG
1
;
Wei YAO
;
Guanghong DING
Author Information
1. Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China.
- Publication Type:Journal Article
- MeSH:
Blood Flow Velocity;
Blood Pressure;
physiology;
Cerebrovascular Circulation;
physiology;
Homeostasis;
Humans;
Hypotension;
physiopathology;
Models, Biological;
Oxygen;
metabolism;
Regional Blood Flow
- From:
Journal of Biomedical Engineering
2009;26(5):1115-1123
- CountryChina
- Language:Chinese
-
Abstract:
Utilizing the third-order polynomial curve fitted to the experimental data, which represents the relationship between cerebral blood flow (CBF) and mean artery blood pressure (MABP), we constructed a lumped-parameter dynamic model with 5 elements. In this model; the resistance is not constants it is determined by the fitted curve. We simulated the process of CBF autoregulation numerically by solving the govern equation of this model and got quite accurate results. Furthermore, we studied the influence of hemodynamic parameters on the CBF autoregulation by this model and proved that the characteristic resistance is the most important factor.
