Lentinan induces the expression of human-beta-defensin-2 in pulmonary epithelial cells.
- Author:
Yan ZHOU
1
;
Birong DONG
;
Lihua TENG
;
Hui WANG
Author Information
1. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- MeSH:
Adjuvants, Immunologic;
pharmacology;
Epithelial Cells;
metabolism;
Humans;
Lentinan;
pharmacology;
Lung;
cytology;
metabolism;
RNA, Messenger;
genetics;
metabolism;
beta-Defensins;
genetics;
metabolism
- From:
Journal of Biomedical Engineering
2009;26(6):1311-1314
- CountryChina
- Language:Chinese
-
Abstract:
To determine whether lentinan could upregulate the expression of human-beta-defensin-2(HBD-2) in pulmonary epithelial cells (SPC-A-1), we stimulated pulmonary epithelial cells with lentinan and detected the expression of HBD-2mRNA by RT-PCR test. The results demonstrated that the expression of HBD-2mRNA in SPC-A-1 could be induced by lentinan in a concentration and time-dependent manner.
