Tri-dimensional omics analysis on effect of zhuanggu zhitong capsule against experimental postmenopausal osteoporosis.
- Author:
Jin-Ping LI
;
Ying ZENG
;
Xiao-Ming LEI
;
Guo-Min ZHANG
;
Hui-Ping LIU
;
Xin-Min MO
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
chemistry;
therapeutic use;
Female;
Gene Expression;
drug effects;
Genomics;
Humans;
Osteoporosis, Postmenopausal;
drug therapy;
genetics;
metabolism;
Proteomics
- From:
China Journal of Chinese Materia Medica
2014;39(16):3203-3207
- CountryChina
- Language:Chinese
-
Abstract:
To propose the new concept of multidimensional omics, and define that the multidimensional omics is a proper method for studying the material base and mechanism of traditional Chinese medicine (TCM) compounds. Zhuanggu Zhitong capsule was taken for example to study its effect against experimental postmenopausal osteoporosis. From the perspective of chemi-omics, genomics and proteomics of TCM, it systematically interpreted the efficacious materials and mechanisms of Zhuanggu Zhitong capsule in preventing and treating experimental postmenopausal osteoporosis, while taking the lead in designing a three dimensional form to intuitively exhibit the results of the multidimensional omics study. This study provides a new idea and solution for studies on the efficacious materials and mechanisms of TCM compounds.
