MicroRNA and left ventricular hypertrophy.
- Author:
Lian DUAN
;
Xing-jiang XIONG
;
Yong-mei LIU
;
Jie WANG
- Publication Type:Journal Article
- MeSH:
Essential Hypertension;
Humans;
Hypertension;
complications;
genetics;
Hypertrophy, Left Ventricular;
complications;
genetics;
MicroRNAs;
genetics;
Risk Factors;
Signal Transduction;
genetics
- From:
China Journal of Chinese Materia Medica
2014;39(17):3211-3215
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNA) plays an important role in biological development and disease occurrence and development, and acts as a "main switch" in biology. Among patients of essential hypertension, around 1/3 would suffer left ventricular hypertrophy (LVH). Hence, essential hypertension becomes an independent risk factor for cardiovascular diseases. And miRNAs plays an important role in the occurrence and development of LVH. This paper reviewed the role of miRNA in regulating the stress signaling pathway, defined its impact on the occurrence of LVH, and further emphasized the opportunities and challenges of miRNA as a biomarker and therapeutic target.
