Advance in studies on molecular mechanisms of cisplatin resistance and intervention with traditional Chinese medicines.
- Author:
Lei LIU
;
Ka BIAN
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
administration & dosage;
pharmacology;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Apoptosis;
drug effects;
Cell Cycle;
drug effects;
Cisplatin;
administration & dosage;
pharmacology;
Drug Resistance, Neoplasm;
drug effects;
Drugs, Chinese Herbal;
administration & dosage;
Humans;
Medicine, Chinese Traditional;
methods;
trends;
Neoplasms;
drug therapy;
pathology;
therapy
- From:
China Journal of Chinese Materia Medica
2014;39(17):3216-3220
- CountryChina
- Language:Chinese
-
Abstract:
Cisplatin is a first-line anticancer drug widely used in clinic. However, its resistance reduces its efficacy. With a non-specific cell cycle, cisplatin's main targets are nucleophilic protein, DNA and RNA in cells. Among cisplatin's multi-factorial resistance mechanisms, abnormal expression of transport protein, intracellular detoxification enhancement, DNA repair capacity increase and apoptosis blocking are the main mechanisms. Because traditional Chinese medicines (TCMs) have unique advantages in cancer treatment, their combination with cisplatin can improve the efficacy. In this paper, the authors summarized the advance in studies on cisplatin's resistance and the combination of TCMs and cisplatin in recent years.
