Studies on release behavior of sustained release tablets of extracts of Gardenia by antioxidant activity.
- Author:
Yi-wang GUO
;
Zhuang ZHAO
;
Yan-ke CHENG
;
Di WANG
;
Shou-ying DU
;
Yang LU
- Publication Type:Journal Article
- MeSH:
Antioxidants;
metabolism;
pharmacology;
Biphenyl Compounds;
metabolism;
Delayed-Action Preparations;
metabolism;
pharmacokinetics;
Free Radicals;
metabolism;
Gardenia;
chemistry;
Kinetics;
Linear Models;
Oxidation-Reduction;
drug effects;
Picrates;
metabolism;
Plant Extracts;
metabolism;
pharmacokinetics;
Tablets
- From:
China Journal of Chinese Materia Medica
2014;39(17):3274-3277
- CountryChina
- Language:Chinese
-
Abstract:
Using sustained release tablets of gardenia extract as model drug and DPPH radical scavenging capacity as antioxidant index, the feasibility of using pharmacodynamics index was explored to evaluate sustained release tablets. Applying the established quantifiable method of DPPH radical scavenging to the dissolved liquid of model drug, release profiles and biological effects profiles were drawn, and their correlation was discussed. A good correlation was observed by linear regression and f2 actor, suggesting that the indicator could be used to evaluate sustained release tabletsofextracts of gardenia in which iridoids were mainly involved.
