Effect of suet oil on formation of self-assembled micelles of flavonoids in Epimedium.
- Author:
Jie LI
;
E SUN
;
Zhen-hai ZHANG
;
Jun JIANG
;
Feng-juan XU
;
Xiao-bin JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Chemistry, Pharmaceutical;
methods;
China;
Drug Carriers;
chemistry;
Electric Conductivity;
Epimedium;
chemistry;
growth & development;
Fatty Acids;
chemistry;
Flavonoids;
chemistry;
Geography;
Goats;
Humans;
Micelles;
Oils;
chemistry;
Sheep
- From:
China Journal of Chinese Materia Medica
2014;39(17):3278-3282
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, the action of suet oil in the preparation of self-assembled micelles of the active flavonoids in Epimedium in the simulated human environment was researched. Twelve suet oil samples were collected from different growing areas and different positions of sheep or goat to simulate the formation of micelles. Then the effects of the fatty acids in suet oil on the preparation of self-assembled micelles were studied furthermore. The results showed that the micelles had a dispersed state and spherical smooth surface. To compare the diameter, potential, encapsulation efficiency and drug loading of the 12 batches micelles, the micelles prepared by the suet oil from Qinghai were more stable and had a higher encapsulation efficiency. The fatty acids in suet oil could promote the formation of self-assembled micelles, but the whole suet oil had a better effect. Above all the study, we confirmed that the suet oil promoted the formation of self-assembled micelles of the flavonoids in Epimedium, it laid foundation for further research about increasing the efficacy of Epimedium and improved the absorption of the active flavonoids in Epimedium.
