A meningomyelocele with normal intracranial signs on ultrasound and false-negative amniotic fluid alpha-fetoprotein and acetylcholinesterase.
10.5468/ogs.2014.57.3.223
- Author:
Chong Hyeok YOON
1
;
Sang Kyu KANG
;
Chan Hee JIN
;
Moon Sun PARK
;
Jeong Hoon RHO
Author Information
1. Department of Obstetrics and Gynecology, Eulji University Medical Center, Eulji University College of Medicine, Daejeon, Korea. rho27kim@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Intracranial sign;
Meningocele;
Meningocele repair;
Maternal serum alpha-fetoproteins;
Spinal dysraphism
- MeSH:
Acetylcholinesterase*;
alpha-Fetoproteins*;
Amniotic Fluid*;
Biochemistry;
Cesarean Section;
Diagnosis;
Down Syndrome;
Female;
Fetus;
Humans;
Meningocele;
Meningomyelocele*;
Neural Tube Defects;
Pregnancy;
Pregnancy Trimester, Second;
Prenatal Diagnosis;
Reference Values;
Spinal Dysraphism;
Ultrasonography*
- From:Obstetrics & Gynecology Science
2014;57(3):223-227
- CountryRepublic of Korea
- Language:English
-
Abstract:
Neural tube defects are the major targets of prenatal diagnoses, along with Down syndrome. Prenatal diagnosis of spina bifida is possible at second trimester of gestation through alpha-fetoprotein and acetylcholinesterase biochemistry assays and ultrasound. In particular, the discovery of characteristic intracranial signs on ultrasound leads to a very high diagnosis rate. However, it is rare for spina bifida to present without intracranial signs while also showing normal values of maternal serum alpha-fetoprotein, amniotic fluid alpha-fetoprotein, and acetylcholinesterase. In our hospital, a fetus with spina bifida was delivered at 37+5 weeks' gestation by cesarean section, and was continually followed up over 2 years to date.
