Comparative analysis of seven marine biological source of mineral drugs.
- Author:
Wei SI
;
Ru-na A
;
Shang-rong LI
;
Jing-Xian ZHANG
;
Wan-ying WU
;
Ya-jun CUI
- Publication Type:Journal Article
- MeSH:
Amino Acids;
analysis;
chemistry;
Animal Shells;
chemistry;
Animals;
Calcium Carbonate;
analysis;
chemistry;
Crystallization;
Edetic Acid;
chemistry;
Mollusca;
chemistry;
classification;
Pharmaceutical Preparations;
analysis;
chemistry;
standards;
Quality Control;
Reproducibility of Results;
Seawater;
Species Specificity;
Spectrophotometry, Ultraviolet;
X-Ray Diffraction
- From:
China Journal of Chinese Materia Medica
2014;39(17):3321-3325
- CountryChina
- Language:Chinese
-
Abstract:
The marine biological source of mineral drugs recorded in Chinese Pharmacopoeia (2010 version) mainly including pearl, nacre, clam shell, common oyster shell, ark shell, cuttle bone, and sea-ear shell are widely used in clinical. Calcium carbonate and a small amount of protein are the main components in this type of drugs. In this paper, a systematical and comparable study were carried out by determination of calcium carbonate by EDTA titration method, the crystal of calcium carbonate by X-Ray powder diffraction and the total amino acids (TAAs) of the hydrolyzed samples by ultraviolet spectrophotometry method. As a result, the crystal structure is calcite for common oyster shell, mixture of calcite and aragonite for nacre and sea-ear shell, aragonite for the other drugs. The content of calcium carbonate ranged from 86% to 96%. Cuttle bone has the highest amount of TAAs among the seven drugs which reached 1.7% while clam shell has the lowest content of 0.16% on average. In conclusion, an effective method was developed for the quality control of marine mineral drugs by comprehensive analysis of calcium carbonate and TAAs in the seven marine mineral drugs.
