Gram-negative resistance in Singapore: a historical perspective.
- Author:
Tse Hsien KOH
1
Author Information
1. Department of Pathology, Singapore General Hospital, Singapore. koh.tse.hsien@sgh.com.sg
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
pharmacology;
Carbapenems;
pharmacology;
Cephalosporins;
pharmacology;
Drug Resistance, Microbial;
Gram-Negative Bacteria;
drug effects;
History, 20th Century;
History, 21st Century;
Humans;
Microbial Sensitivity Tests;
Quinolones;
pharmacology;
Singapore;
beta-Lactamases;
genetics
- From:Annals of the Academy of Medicine, Singapore
2008;37(10):847-854
- CountrySingapore
- Language:English
-
Abstract:
In the past 3 decades, classical extended-spectrum beta-lactamases (ESBLs) have probably been the main contributors to gram-negative antimicrobial resistance in Singapore. These appear to be being replaced by the newer CTX-M ESBLs. Metallo-beta-lactamases are found in Pseudomonas aeruginosa but do not seem to have spread widely in Acinetobacter spp. and Enterobacteriaceae. Carbapenem-hydrolysing oxacillinases are prevalent in multidrug-resistant Acinetobacter spp. More insidious developments include the emergence of plasmid AmpC beta-lactamases and multifactorial quinolone resistance in Enterobacteriaceae.
