The association of smoking with components of the metabolic syndrome in non-diabetic patients.

Mojgan Gharipour; Roya Kelishadi; Nizal Sarrafzadegan; Abdolmehdi Baghaei; Mehrdad Yazdani; Jafar Anaraki; Babak Eshrati; Ali Akbar Tavassoli

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The association of smoking with components of the metabolic syndrome in non-diabetic patients.

Author: Mojgan GHARIPOUR ¹ ; Roya KELISHADI ; Nizal SARRAFZADEGAN ; Abdolmehdi BAGHAEI ; Mehrdad YAZDANI ; Jafar ANARAKI ; Babak ESHRATI ; Ali Akbar TAVASSOLI
Author Information

1. Biochemistry Department, Isfahan Cardiovascular Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran. gharipour@crc.mui.ac.ir
Publication Type:Journal Article
MeSH: Adult; Biomarkers; blood; Blood Pressure; Body Mass Index; Cholesterol, HDL; blood; Cholesterol, LDL; blood; Cross-Sectional Studies; Diabetes Mellitus; Female; Follow-Up Studies; Humans; Iran; epidemiology; Male; Metabolic Syndrome; blood; epidemiology; etiology; Prevalence; Retrospective Studies; Smoking; adverse effects; blood; epidemiology; Triglycerides; blood; Waist-Hip Ratio
From:Annals of the Academy of Medicine, Singapore 2008;37(11):919-923
CountrySingapore
Language:English
Abstract:
INTRODUCTIONThere is limited evidence about the association between smoking and metabolic syndrome (MS). The aim of this study was to assess the association of smoking with MS components.
MATERIALS AND METHODSAs part of the baseline survey of a community-based study, we studied 5,573 non-diabetic men. All participants were interviewed and underwent physical examinations and blood collection.
RESULTSThe study participants comprised 1,625 smokers and 3,948 non-smokers, with a mean age of 38.07 +/- 14.85 years. Serum low-density lipoprotein-cholesterol (LDL-C) and triglycerides (TG) were higher in smokers than in non-smokers (LDLC: 115.34 +/- 39.03 vs 112.65 +/- 40.94 mg/dL, respectively, P = 0.015 and TG: 175.13 +/- 102.05 vs 172.32 +/- 116.83 mg/dL, respectively, P = 0.005). Body mass index, waist circumference and waist-hip ratio were lower in smokers than in non-smokers. Mean systolic and diastolic blood pressures were significantly lower in smokers than in non-smokers (systolic: 112.06 +/- 15.888 vs 117.25 +/- 17.745 mmHg, respectively, P = 0.000; diastolic: 73.66 +/- 10.084 vs 76.23 +/- 10.458 mmHg, respectively, P = 0.000). The percentage of individuals with 2 MS components was higher in smokers than in non-smokers (39.64% vs 33.00%, respectively, P = 0.000). However, the percentage of non-smokers with 3 MS components was higher than in smokers (49.62 % vs 43.82%, respectively, P = 0.000).
CONCLUSIONSOur findings support the hypothesis that lifestyle factors such as smoking can adversely affect MS components. However, we should acknowledge that these differences may have resulted from the large sample sizes studied and may not be clinically significant. The lower prevalence of some MS components in smokers than in nonsmokers might be because of their lower anthropometric measures.