Myocardial infarction following recombinant tissue plasminogen activator treatment for acute ischemic stroke: a dangerous complication.
- Author:
Zhi-Gang ZHOU
1
;
Rui-Lan WANG
;
Kang-Long YU
Author Information
1. Department of Emergency and Intensive Care Medicine, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai 201620, China.
- Publication Type:Case Reports
- MeSH:
Humans;
Male;
Middle Aged;
Myocardial Infarction;
diagnosis;
etiology;
Stroke;
complications;
drug therapy;
Tissue Plasminogen Activator;
therapeutic use
- From:
Chinese Medical Journal
2012;125(15):2775-2776
- CountryChina
- Language:English
-
Abstract:
Thrombolysis with intravenous tissue plasminogen activator (t-PA) is currently an approved therapy for patients with acute ischemic stroke. Acute myocardial infarction (AMI) immediately following t-PA treatment for stroke is a rare but serious complication. A case of acute myocardial infarction (MI) following IV t-PA infusion for acute stroke was observed. This is a 52-year-old male with a known history of hypertension and chest pain, who subsequently developed MI four hours after IV t-PA was administered for acute ischemic stroke. The disruption of intra-cardiac thrombus and subsequent embolization to the coronary arteries may be an important mechanism. In addition, spontaneous recanalization of infarct-related arteries may be associated with greater myocardial salvage and better prognosis.
