A case-control study on family history of Alzheimer's disease.
- Author:
Jiahong YAO
1
;
Hui LI
;
Zhenxin ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Alzheimer Disease; genetics; Case-Control Studies; China; Dementia; genetics; Family Health; Female; Humans; Male; Middle Aged; Psychotic Disorders; genetics
- From: Chinese Journal of Epidemiology 2002;23(1):54-56
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between Alzheimer's disease and its family history of the patients.
METHODSStratified analyses and logistic regression analysis were used to examine the association between Alzheimer's disease and its family history exposure in 127 cases and 254 matched controls from a population-based case-control study.
RESULTSThe risk of Alzheimer's disease was significantly higher in those who had at least one first-degree relative with dementia or major psychosis as compared to those who had no dementia or major relatives with psychosis (OR = 6.25; 8.33). Adjusted for age and level of education, family history of dementia was still associated with Alzheimer's disease positively (OR = 2.07).
CONCLUSIONThis study provides evidence that familial aggregation of Alzheimer's disease might exist among people living Beijing.
