A molecular epidemiological study of childhood lead poisoning in lead-polluted environment.
- Author:
Yuxin ZHENG
1
;
Shuguang LENG
;
Wenjia SONG
;
Yawen WANG
;
Yong NIU
;
Wenzhong ZHANG
;
Huifang YAN
;
Yuying LIU
;
Qingxiao HUANG
;
Yiqun WU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Body Height; drug effects; genetics; Body Weight; drug effects; genetics; Child; China; epidemiology; Environmental Pollution; adverse effects; Female; Gene Frequency; Genotype; Humans; Lead; adverse effects; blood; Lead Poisoning; epidemiology; etiology; genetics; Male; Polymorphism, Genetic; Porphobilinogen Synthase; genetics; Receptors, Calcitriol; genetics
- From: Chinese Journal of Epidemiology 2002;23(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEThe relationship between polymorphisms of ALAD and VDR genes and individual susceptibility of lead poisoning was investigated in children highly-exposed to lead.
METHODFour hundred and sixty-nine children were recruited into this study and the blood lead, ZPP, hemoglobin as well as three physical developmental indexes (head circumference, height and weight) were measured. VDR and ALAD gene polymorphisms were analyzed by the methods of PCR-RFLP.
RESULTSThe subjects with ALAD2 allele had higher ZPP level (10.12 micro mol/L vs 12.87 micro mol/L) (P = 0.017). The subjects with B allele has larger head circumference than only with b allele (51.19 cm vs 50.75 cm) (P = 0.028).
CONCLUSIONSIt was suggested that the ALAD gene polymorphism modified the relationship between blood lead and ZPP and the VDR gene variants influenced the skull development in children living under lead-polluted environment. The polymorphism of ALAD and VDR genes might serve as the molecular inherited factors modifying the susceptibility of lead poisoning.
