Studies on the safety and immunogenicity of lyophilized live attenuated measles-mumps-rubella combined vaccine.
- Author:
Guohua LIU
1
;
Hanhua FANG
;
Zijian FENG
;
Wanshen GUO
;
Chunming DONG
;
Wenping ZHANG
;
Wenyuan ZE
Author Information
- Publication Type:Journal Article
- MeSH: Antibodies, Viral; blood; Child; Child, Preschool; Freeze Drying; Hemagglutination Inhibition Tests; Humans; Measles-Mumps-Rubella Vaccine; adverse effects; immunology; Vaccines, Attenuated; adverse effects; immunology
- From:Chinese Journal of Epidemiology 2002;23(6):435-437
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the safety and immunogenicity of the measles-mumps-rubella combined vaccine (MMR) produced by Beijing Biological Product Institute.
METHODSChildren aged 10-12 years, 2-2.5 years and 8-12 months were selected to be vaccinated with Beijing MMR vaccine (test vaccine). Other groups of children with similar nature were vaccinated with measles vaccine, mumps vaccine and rubella vaccine while using imported MMR vaccine (control vaccine) as controls.
RESULTSThe safety of the Beijing MMR vaccine was confirmed after vaccinating 32 children above 2 years old. Among 104 children of 8-12 months were vaccinated with Beijing MMR vaccine, only 6.7% of the children had transient fever and 1.9% had signs of rashes but with no other signs observed. The positive seroconversion rates of measles, rubella and mumps anti-HI were 100%, 100% and 85.7% respectively. GMT also showed high lever.
CONCLUSIONThe MMR vaccine (Beijing) had good safety and immunogenicity which might be used to be the bases enhance immunization of measles.
