Study of the association between HLA-DQA1 alleles and environmental factors in psoriasis.
- Author:
Shengcai WEI
1
;
Min GAO
;
Xuejun ZHANG
;
Sen YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Alleles; Case-Control Studies; Child; Child, Preschool; Environment; Female; HLA-DQ Antigens; genetics; HLA-DQ alpha-Chains; Humans; Male; Psoriasis; etiology; genetics; immunology
- From: Chinese Journal of Epidemiology 2002;23(6):445-448
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study of the HLA-DQA(1) alleles and environment interaction in type I psoriasis.
METHODSUsing case-control study, 144 type I psoriatics and 273 healthy people were investigated. The HLA-DQA(1) alleles were examined by PCR-SSP.
RESULTS(1) HLA-DQA(1)*0104 and DQA(1)*0201 alleles were positively associated with type I psoriasis (P(c) < 0.002); HLA-DQA(1)*0501 allele was negatively associated with type I psoriasis (P(c) < 0.000 5). (2) The HLA-DQA(1)*0104 allele and moisture was interaction in type I psoriasis (P = 0.023 8, OR = 5.29). (3) There were no interactions between the HLA-DQA(1)*0201 allele and 10 environmental factors in type I psoriasis. (4) The HLA-DQA(1)*0501 allele, moisture (P = 0.002 4, OR = 7.50), eating fish and shrimp (P = 0.000 4, OR = 12.92), drugs (P = 0.043 3, OR = 9.43) or vaccination (P = 0.043 3, OR = 9.43) were interacted in type I psoriasis.
CONCLUSIONS(1) HLA-DQA(1)*0104 and DQA(1)*0201 alleles might be the susceptible genes or it may have close linkage with the susceptible gene. HLA-DQA(1)*0501 allele had protective effect against the development of type I psoriasis. (2) The HLA-DQA(1)*0104 and DQA(1)*0501 alleles increased risk possibility of environmental factors in type I psoriasis.
