Detection of SEN virus in sera of patients with chronic hepatitis B and general population in 5 cities of China.
- Author:
Jie YAN
1
;
Zhong-ping HE
;
Hui ZHUANG
;
Qing-ming DONG
;
Shu-jing SONG
;
Lin ZHU
;
Xiao-hong WANG
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Circoviridae; isolation & purification; Circoviridae Infections; complications; epidemiology; virology; DNA Virus Infections; complications; epidemiology; virology; DNA Viruses; isolation & purification; DNA, Viral; analysis; Hepatitis B, Chronic; complications; virology; Humans; Phylogeny; Prevalence
- From:Chinese Journal of Epidemiology 2003;24(1):33-35
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the prevalence of SEN virus (SENV) infection in CHB patients in five cities of China.
METHODSA nest-polymerase chain reaction (nPCR) was used for detection of SENV-D and SENV-H in sera of 595 CHB patients from 5 cities of China and 96 normal individuals from Beijing. A total of 7 SENV strains were analyzed by direct sequencing.
RESULTSThe prevalence rates of SENV in CHB patients and normal individuals were 61.3% and 62.5%, respectively (chi(2) = 0.047, P = 0.829). The prevalence rates of CHB patients between 5 cities were different. Nucleotide sequence analysis showed that the homology between 4 SENV-D strains was 91% - 98% and 95% - 98% between 3 SENV-H strains isolated from 5 cities in China.
CONCLUSIONSENV-D/H were prevalent in CHB patients of China and their prevalence rates were similar to that in normal individuals.
