Study on risk factors and molecular typing of Acinetobacter baummanii in nosocomial infections.

Ding Liu; Ping Chen; Wei Chen; Xiang-qun Lian; Zhi-hai YU

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Study on risk factors and molecular typing of Acinetobacter baummanii in nosocomial infections.

Author: Ding LIU ¹ ; Ping CHEN ; Wei CHEN ; Xiang-qun LIAN ; Zhi-hai YU
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1. Center of Nosocomial Infection, The Daping Hospital, The Third Military Medical University, Chongqing 400042, China.
Publication Type:Journal Article
MeSH: Acinetobacter baumannii; classification; genetics; Cross Infection; etiology; microbiology; Genotype; Humans; Logistic Models; Polymerase Chain Reaction; Risk Factors
From: Chinese Journal of Epidemiology 2003;24(2):140-142
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the risk factors of Acinetobacter baummanii in nosocomial infections, and to verify the nature of Acinetobacter baumannii strains isolated from intensive care unit (ICU).
METHODSA hundred and fourty patients associated with nosocomial infection of Acinetobacter baummanii from four teaching hospitals were selected and compared with controls through a case control study to identify risk factors. The strains isolated from the ICU were typed by polymerase chain reaction (PCR) with the primer M(13) following electrophoresis in agarose gel.
RESULTSThe odds ratios (ORs) were: state of the illness (OR = 8.69), using immunosuppressant (OR = 4.85), mechanical ventilation (OR = 3.68) and treatment with 3 kinds of antibiotics (OR = 3.014). Data from PCR studies indicated that these strains were sharing identical band pattern from the five strains.
CONCLUSIONRisk factors for nosocomial infection with Acinetobacter baummanii included state of an illness, immunosuppressant, mechanical ventilation, and treatment with antibiotics. A multidrug-resistant strains of Acinetobacter baumannii was identified in ICU.