Virtual histology intravascular ultrasound assessment of coronary atherosclerotic plaques in diabetic patients.
- Author:
Yuan LIU
1
;
Xue-bo LIU
;
Ju-ying QIAN
;
Chen-guang LI
;
Yu-xiang DAI
;
Zhe-yong HUANG
;
Jun-ba GE
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Case-Control Studies; Coronary Artery Disease; diagnostic imaging; etiology; Coronary Vessels; diagnostic imaging; Diabetes Mellitus, Type 2; complications; diagnostic imaging; pathology; Female; Humans; Male; Middle Aged; Plaque, Atherosclerotic; diagnostic imaging; etiology; Ultrasonography, Interventional; methods
- From: Chinese Journal of Cardiology 2010;38(6):497-502
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the components and characteristics of coronary atherosclerotic plaques in type 2 diabetic patients using virtual histology intravascular ultrasound (VH-IVUS).
METHODSIn vivo atherosclerotic plaques (over 50% angiographic diameter stenosis) of the three main coronary arteries were analyzed by gray-scaled IVUS with planar and volumetric VH-IVUS in consecutive patients examined between September 2008 and March 2009. Patients were divided into two groups: diabetic mellitus (DM) group with 22 patients (39 lesions) and non-DM group with 46 patients (69 lesions).
RESULTSAt the minimal lumen area (MLA) site, the percentage of NC (necrotic core) area (19.4% +/- 1.2% vs. 15.1% +/- 1.1%, P = 0.015) and dense calcium (DC) area (15.2% +/- 1.6% vs. 10.7% +/- 1.1%, P = 0.016) were significantly larger while fibrotic tissue (FT) area (56.7% +/- 2.3% vs. 64.8% +/- 1.8%, P = 0.007) was smaller in DM group than in non-DM group. Likewise, volumetric VH-IVUS analysis showed that the percentage of NC volume (21.3% +/- 1.3% vs. 16.5% +/- 1.1%, P = 0.008) and DC volume (16.6% +/- 1.4% vs. 11.3% +/- 1.1%, P = 0.003) were significantly larger while FT volume (55.1% +/- 2.1% vs. 63.9% +/- 1.8%, P = 0.003) was significantly smaller in DM group than in non-DM group. Moreover, significantly higher incidence of VH-TCFA (thin-cap fibro atheromas) was evidenced in the DM group than in the non-DM group (69.2% vs. 42.0%, P = 0.009). However, the remodeling index and the positive remodeling frequency were similar between the 2 groups.
CONCLUSIONIncidence of necrotic core, dense calcium plaque and vulnerable plaques in stenotic lesions was higher in DM patients than in non-DM patients.