Virtual histology intravascular ultrasound assessment of coronary atherosclerotic plaques in diabetic patients
10.3760/cma.j.issn.0253-3758.2010.06.005
- VernacularTitle:糖尿病患者冠状动脉粥样硬化病变的虚拟组织学血管内超声研究
- Author:
Yuan LIU
1
;
Xue-Bo LIU
;
Ju-Ying QIAN
;
Chen-Guang LI
;
Yu-Xiang DAI
;
Zhe-Yong HUANG
;
Jun-Bo GE
Author Information
1. 复旦大学附属中山医院
- Keywords:
Diabetes mellitus,type 2;
Coronary arteriosclerosis;
Ultrasonography,interventional
- From:
Chinese Journal of Cardiology
2010;38(6):497-502
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the components and characteristics of coronary atherosclerotic plaques in type 2 diabetic patients using virtual histology intravascular ultrasound (VH-IVUS). Methods In vivo atherosclerotic plaques ( over 50% angiographic diameter stenosis ) of the three main coronary arteries were analyzed by gray-scaled IVUS with planar and volumetric VH-IVUS in consecutive patients examined between September 2008 and March 2009. Patients were divided into two groups: diabetic mellitus (DM) group with 22 patients (39 lesions) and non-DM group with 46 patients (69 lesions). Results At the minimal lumen area (MLA) site, the percentage of NC (necrotic core) area (19.4% ± 1.2% vs.15.1% ± 1.1%, P =0. 015) and dense calcium (DC) area (15.2% ± 1.6% vs. 10. 7% ± 1.1%, P =0. 016) were significantly larger while fibrotic tissue (FT) area (56. 7% ±2. 3% vs. 64. 8% ± 1.8%, P =0. 007) was smaller in DM group than in non-DM group. Likewise, volumetric VH-IVUS analysis showedthat the percentage of NC volume (21.3% ± 1.3% vs. 16. 5% ± 1.1%, P = 0. 008) and DC volume (16.6% ±1.4% vs. 11.3% ±1.1%, P=0.003) were significantly larger while FT volume (55. 1% ±2. 1% vs. 63.9% ± 1.8%, P =0.003) was significantly smaller in DM group than in non-DM group.Moreover, significantly higher incidence of VH-TCFA (thin-cap fibroatheromas) was evidenced in the DM group than in the non-DM group (69. 2% vs. 42. 0%, P =0. 009). However, the remodeling index and the positive remodeling frequency were similar between the 2 groups. Conclusion Incidence of necrotic core, dense calcium plaque and vulnerable plaques in stenotic lesions was higher in DM patients than in non-DM patients.
