Predictive value of human fatty acid binding protein for myocardial ischemia and injury in perioperative period of cardiac surgery.
- Author:
Yin-he LIU
1
;
Yi-wen ZHOU
;
Zhi-guang TU
;
Shang-yi JI
;
Man CHEN
;
Zhi-yong HUANG
;
Jian-an YANG
;
R RENNEBERG
;
Yi WANG
;
Zhi-yong NIE
;
An ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Albumins; analysis; Biomarkers; blood; Creatine Kinase, MB Form; blood; Fatty Acid-Binding Proteins; blood; Humans; Middle Aged; Myocardial Ischemia; diagnosis; surgery; Myocardium; metabolism; Perioperative Period; Predictive Value of Tests; Thoracic Surgery; Troponin I; blood
- From: Chinese Journal of Cardiology 2010;38(6):514-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of human fatty acid binding protein (h-FABP) in predicting myocardial ischemia and injury in the perioperative period of cardiac surgery, we observed the dynamic changes of h-FABP in perioperative period of patients underwent coronary artery bypass grafting and ventricular septal defects repairing surgery, and evaluated the relationship of h-FABP and ischemia modified albumin (IMA), CK-MB, cTnI.
METHODSPatients underwent coronary artery bypass grafting (n=30) and ventricular septal defect repairing (n=30) surgery between February 2008 and December 2008 were included in this study. Venous blood sample was obtained at preoperative, aortic clamping, aortic unclamping of 10 min, 2 h, 6 h, 12 h, 24 h for the measurements of h-FABP, IMA, cTnI and CK-MB.
RESULTSh-FABP and IMA changed in the same way at various examined time points, h-FABP changes also paralleled cTnI and CK-MB changes, h-FABP peaked early during myocardial ischemia and injury and returned to baseline level at 2 h post myocardial ischemia and injury. Linear correlation analysis showed that the peak value of h-FABP was positively correlated with IMA, CK-MB and cTnI in both CABG group (r = 0.948, 0.964 and 0.961, P < 0.05) and in the VSD group (r = 0.986, 0.978 and 0.957).
CONCLUSIONSh-FABP is an early diagnostic parameter reflecting perioperative myocardial ischemia and injury in cardiac surgery. Quantitative h-FABP monitoring could predict the severity of myocardial ischemia and injury early during cardiac surgery.