Extracorporeal cardiac shock wave therapy for treatment of coronary artery disease
10.3760/cma.j.issn.0253-3758.2010.08.008
- VernacularTitle:体外心脏震波治疗冠心病的应用研究
- Author:
Yu WANG
1
;
Tao GUO
;
Hong-Yan CAI
;
Tie-Kun MA
;
Si-Ming TAO
;
Ming-Qing CHEN
;
Yun GU
;
Jia-Hua PAN
;
Jian-Ming XIAO
;
Ling ZHAO
;
Xi-Yun YANG
;
Chao YANG
Author Information
1. 昆明医学院附属第一医院
- Keywords:
Myocardial infarction;
Angina,unstable;
Neovascularization,physiologic;
Extracorporeal cardiac shock wave therapy
- From:
Chinese Journal of Cardiology
2010;38(8):711-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and efficiency of extracorporeal cardiac shock wave therapy(CSWT)for treatment of coronary artery disease. Methods Twenty-five patients with 1-16 years history of chronic angina pectoris underwent the CSWT. Before and after the treatment, low -dose Dobutamine stress echocardiography and 99Tcm-MIBI myocardial perfusion SPECT were applied to locate the ischemic segments, detect the viable myocardium and evaluate the effect of CSWT. Under the guidance of echocardiography, CSWT was applied in R-wave-triggered manner with low energy(0. 09 mJ/mm2)at 200 shoots/spot for9 spots(-1 -0- + 1 combination). Patients were divided group A and group B. Sixteen patients in group A were applied 9 sessions on 29 segments within 3 month and nine patients in group B were applied 9 sessions on 13 segments within 1 month. Ten chronic angina pectoris patients receiving standard medication served as controls. Results All patients completed the 9 sessions without procedural complications or adverse effects. CSWT significantly improved symptoms as evaluated by NYHA, Canadian Cardiovascular Society(CCS)class sores, Seattle angina questionnaire(SAQ), 6-min walk and the use of nitroglycerin(P＜0. 05). CSWT also improved myocardial perfusion and regional myocardium function as evaluated by rest SPECT and stress peak systolic strain rate(PSSR)(P ＜ 0. 01). Myocardial perfusion improvement was more significant in group A compared with group B(1.21 ± 0. 86 vs. 0. 83 ± 0. 80, P ＜0. 01). All parameters remained unchanged in control group during follow up. Conclusion These preliminary results indicate that CSWT is safe and effective on ameliorating anginal symptoms for chronic angina pectoris patients.
