Evaluation of the myocardial systolic function and ventricular remodeling of rats with experimental myocardial infarction by strain/strain rate imaging and MMP-9.
- Author:
Wen-hui ZHU
1
;
Xing-xing DUAN
;
Meng-xi ZHANG
;
Shui-juan TANG
;
Wen-gang LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Heart Failure; metabolism; physiopathology; Male; Matrix Metalloproteinase 9; metabolism; Myocardial Contraction; Myocytes, Cardiac; metabolism; Rats; Rats, Sprague-Dawley; Systole; Ventricular Remodeling
- From: Chinese Journal of Cardiology 2010;38(7):597-600
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the myocardial systolic function and ventricular remodeling in heart failure rat induced by myocardial infarction (MI) with S/SRI and MMP-9.
METHODSA total of 70 male SD rats were randomly assigned to 4 groups: 4 weeks and 8 weeks MI (anterior descending branch of left coronary artery were ligated), sham operation (thoracotomy without ligation of coronary artery) and non-operated control group. The regional myocardial systolic function of rats was quantified with S/SRI. The myocardial MMP-9 expression was detected by Western blot.
RESULTSIn the 4 weeks MI group, all segment's Ssys, SRsys, the strain of end-systole were reduced while PSI was increased compared to sham and non-operated group with the exception of the inferior wall. These changes were more significant in 8 weeks MI group compared to the 4 weeks MI group. In the 4 weeks MI group, the expression of MMP-9 was significantly upregulated than the sham operation group and this upregulation was more significant at 8 weeks post MI.
CONCLUSIONSS/SRI can quantitative evaluate the regional systolic function of heart failure rat induced by myocardial infarction. Progressive upregulation of myocardial MMP-9 expression paralleled the deterioration of regional systolic function in this heart failure rat model.
