Evaluation of the myocardial systolic function and ventricular remodeling of rats with experimental myocardial infarction by strain/strain rate imaging and MMP-9
10.3760/cma.j.issn.0253-3758.2010.07.006
- VernacularTitle:应变/应变率成像结合基质金属蛋白酶-9评价心力衰竭大鼠心肌收缩功能及心室重构
- Author:
Wen-Hui ZHU
1
;
Xing-Xing DUAN
;
Meng-Xi ZHANG
;
Shui-Juan TANG
;
Wen-Gang LIU
Author Information
1. 中南大学湘雅三医院
- Keywords:
Heart failure,congestive;
Matrix metalloproteinases;
Echocardiography,Doppler;
Strain/strain rate imaging
- From:
Chinese Journal of Cardiology
2010;38(7):597-600
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the myocardial systolic function and ventricular remodeling in heart failure rat induced by myocardial infarction (MI) with S/SRI and MMP-9. Methods A total of 70 male SD rats were randomly assigned to 4 groups: 4 weeks and 8 weeks MI ( anterior descending branch of left coronary artery were ligated ) , sham operation (thoracotomy without ligation of coronary artery ) and nonoperated control group. The regional myocardial systolic function of rats was quantified with S/SRI. The myocardial MMP-9 expression was detected by Western blot Results In the 4 weeks MI group, all segment's Ssys, SRsys, the strain of end-systole were reduced while PSI was increased compared to sham and nomoperated group with the exception of the inferior wall. These changes were more significant in 8 weeks MI group compared to the 4 weeks MI group. In the 4 weeks MI group, the expression of MMP-9 was significantly upregulated than the sham operation group and this upregulation was more significant at 8 weeks post MI. Conclusions S/SRI can quantitative evaluate the regional systolic function of heart failure rat induced by myocardial infarction. Progressive upregulation of myocardial MMP-9 expression paralleled the deterioration of regional systolic function in this heart failure rat model.
