Association between lipoprotein (a) and coronary artery disease
10.3760/cma.j.issn.0253-3758.2010.07.011
- VernacularTitle:血浆脂蛋白(a)与冠心病的相关性研究
- Author:
Guan WANG
1
;
Yan-Fang LI
Author Information
1. 北京中医药大学第三附属医院
- Keywords:
Coronary disease;
Lipoprotein (a)
- From:
Chinese Journal of Cardiology
2010;38(7):618-620
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between plasma level of lipoprotein(a) [ Lp( a) ] and coronary artery disease (CAD). Method A total of 1011 patients underwent coronary angiography in our department from October 2007 to March 2009 due to chest pain were included, 613 cases (60. 6% ) were diagnosed as CAD and the remaining 398 non-CAD patients (39. 4% ) served as control. Lp (a) , apolipoproteinAl ( apoAl ), apolipoproteinB ( apoB) were detected by immunoturbidimetry method, triglyceride (TG), total cholesterol (TC) , high density lipoprotein cholesterol ( HDL-C) and low density lipoprotein cholesterol ( LDL-C) were measured by enzymatic approach. LDL-C/HDL-C ratio was calculated, multivariate logistic regression analysis was performed. Results (1) The values of Lp(a), TC, TC, LDL-C and apoB, and the ratio of LDL-C/HDL-C in CAD group were significantly higher in CAD group [(170.00±160.00)mg/L, (1.84±0.90)mmol/L, (4. 86 ± 0. 88) mmol/L, (3. 31±0. 72) mmol/L, (0. 97 ± 0.17) mmol/L and 3. 39 ± 0. 93 ] compared to those in control group [ (120. 00 ± 100. 00 ) mg/L, (1.67±0.72)mmol/L, (4.61 ± 0.95) mmol/L, (2. 96 ±0. 80) mmol/L, (0. 90±0. 18) mmol/L and 2. 89 ±0.92, all P<0.05]. (2) Multivariate logistic regression analysis (forward method) indicated that Lp(a) (OR = 16. 201, 95% CI3. 477 -75. 489, P = 0. 0001) was the most powerful independent risk factor for diagnosing coronary artery disease. Conclusions Lp(a) is the most powerful independent risk factors for diagnosing coronary artery disease.
