Clinico-pathological evaluation of restrictive cardiomyopathy
10.3760/cma.j.issn.0253-3758.2010.09.006
- VernacularTitle:限制型心肌病的临床和病理评价
- Author:
Zhuang TIAN
1
;
Yong ZENG
;
Quan FANG
;
Da-Chun ZHAO
;
Quan-Cai CUI
;
Kang-An CHENG
;
Li-Gang FANG
;
Peng GAO
;
Zhong-Wei CHENG
;
Xiu-Chun JIANG
;
Rong-Liang SUN
Author Information
1. 中国医学科学院北京协和医学院北京协和医院
- Keywords:
Cardiomyopathy,restrictive;
Pathology,clinical;
Amyloidosis;
Hypereosinophilic syndrome
- From:
Chinese Journal of Cardiology
2010;38(9):786-789
- CountryChina
- Language:Chinese
-
Abstract:
Objective Restrictive cardiomyopathy (RCM) is characterized by impairment of ventricular filling during diastole with preserved systolic function. The clinical and histopathological profile on endomyocardial biopsy of 25 consecutive patients with RCM was analyzed in this study. Methods Twenty-five patients with diagnosis of RCM and underwent endomyocardial biopsy (EMB) were enrolled in the study. The clinical characteristics, electrocardiogram, serum chemistry, right heart catheter and cardiac pathology results were obtained. Results Heart failure symnptom was present in all 25 patients and left ventricular size and function were normal or near normal while serum brain natriuretic peptide(577 pg/ml)was moderately elevated. Right atrial and ventricular end-diastolic as well as pulmonary capillary wedge pressures derived from right heart catheter examination were increased. Amyloid deposition were evidenced in 16 and eosinophilic myocarditis in 2 patients upon pathological examination of EMB. In the remaining 7patients, 3 were diagnosed idiopathic RCM, 2 were diagnosed as amyloidosis by biopsy from non-cardiac tissue and etiology remained unknown in 2 patients. Thus, conclusive diagnosis was made on EMB samples in 84% (21/25) patients of RCM. Conclusion RCM may result from various local and systemic disorders. EMB is helpful for identifying the underlying etiology.
