Plasma asymmetric dimethylarginine and cystatin C levels in patients with coronary artery disease
10.3760/cma.j.issn.0253-3758.2010.09.009
- VernacularTitle:非对称性二甲基精氨酸和胱氨酸蛋白酶抑制剂C与冠心病
- Author:
Ling YOU
1
;
Chun-Xia ZHAO
;
Jiao-Mei SHAO
;
Luo ZHANG
;
Dao-Wen WANG
Author Information
1. 华中科技大学同济医学院附属同济医院
- Keywords:
Coronary disease;
Asymmetric dimethylarginine;
Cysteine proteinase inhibitors
- From:
Chinese Journal of Cardiology
2010;38(9):798-800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare plasma asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, and cystatin C levels in patients with or without coronary artery disease (CAD). Methods We recruited 87 CAD patients (39 with acute myocardial infarction and 48 with unstable angina pectoris ) and 51 non-CAD controls. Plasma ADMA was measured by HPLC, cystatin C by particleenhanced immunonephelometric assay (N Latex cystatin C, Dade Behring) with anephelometer (BNII, Dade Behring). CAD patients were further divided into low cystatin C group ( < 1.0 mg/L, 36 cases) and high cystatin C group ( > 1.0 mg/L, 51 cases). Results ( 1 ) The plasma levels of ADMA [(0. 47 ± 0. 15 )μmol/L vs. (0. 37 ±0. 15) μmol/L], SDMA [(0. 39 ±0. 19) μmol/L vs. (0. 28 ±0. 12) μmol/L] and cystatin C [(1.16 ±0. 32)mg/L vs. (0. 73 ±0. 16)mg/L] were significantly higher in CAD patients than in controls (all P < 0. 05 ). The plasma L-Arg was significantly lower in CAD patients than in controls [(59.4 ± 19.4) μmol/L vs. (83. 7 ± 19. 6) μmol/L, P <0. 05]. (2) Plasma ADMA was similar in CAD patients with low cystatin C level and controls [(0. 42 ±0. 12) μmol/L vs. (0. 39 ±0. 15) μ mol/L, P =0. 251] and Plasma ADMA was significantly higher in CAD patients with high cystatin C level than in controls [(0. 50 ±0. 17) μmol/L vs. (0. 39 ±0. 15) μmol/L, P <0. 05]. Conclusion ADMA levels were significantly increased only in CAD patients with elevated cystatin C levels but not in CAD patients with normal renal function. The reported relationship between coronary heart disease and ADMA may not be direct, but could be secondary due to reduced renal function.
