Statin reduced triglyceride level via activating peroxisome proliferstor activated receptor α and upregulating apolipoprotein A5 in hypertriglyceridemic rats
10.3760/cma.j.issn.0253-3758.2010.09.012
- VernacularTitle:他汀升高大鼠载脂蛋白A5降低甘油三酯的机制
- Author:
Xian-Sheng HUANG
1
;
Shui-Ping ZHAO
;
Lin BAI
;
Qian ZHANG
;
Min HU
;
Wang ZHAO
Author Information
1. 中南大学湘雅二医院
- Keywords:
Apolipoproteins A;
Triglycerides;
PPAR alpha;
Statins
- From:
Chinese Journal of Cardiology
2010;38(9):809-813
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential role of apolipoprotein A5 (apoA5) on the hypertriglyceridemia (HTG)-lowering effects of statin. Methods Twenty-four Sprague-Dawley rats were randomized into 3 groups: ( 1 ) control group ( n = 8), with no special treatment; (2) HTG group (n = 8),treated with 10% fructose water for 6 weeks; (3) statin group(n =8), treated with 10% fructose water for lipids and the hepatic expressions of apoA5 and peroxisome proliferstor activated receptor (PPAR)α were determined. In separate in vitro experiments, we tested the effects of atorvastatin on TG and the expressions of apoA5 and PPARα in HepG2 cells. Results ( 1 ) At 6 weeks, plasma TG was higher in rats in HTG group than in controls, which was significantly reduced in statin group (both P <0. 05). (2) Rat hepatic apoA5 expression in HTG group was significantly lower than in control group and was significantly higher in statin group than in HTG group ( both P < 0. 05 ). (3) Similarly, rat PPARα mRNA expression in HTG group was lower than in control group and was higher in statin group than in HTG group ( both P < 0. 05 ).(4) Statin significantly upregulated the expressions of apoA5 and PPARα and decreased TG in HepG2 cells.The above effects induced by statin was blocked in the presence of PPARα inhibitor. Conclusions Upregulation of apoA5 expression contributes to TG lowering effect of statin via PPARα signaling pathway.
