Association between rs4149601 polymorphism and essential hypertension in Kazakh
10.3760/cma.j.issn.0253-3758.2010.10.012
- VernacularTitle:神经前体细胞表达发育调控样蛋白4基因多态性与哈萨克族高血压病的关联研究
- Author:
Hong-Mei WANG
1
;
Nan-Fang LI
;
Jing HONG
;
Xiao-Guang YAO
;
Wen-Li LUO
;
Jian-Hang CHANG
Author Information
1. 新疆维吾尔自治区人民医院
- Keywords:
Hypertension;
Polymorphism,single nucleotide;
Kazakh
- From:
Chinese Journal of Cardiology
2010;38(10):918-922
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between a functional rs4149601 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene (NEDD4L)and essential hypertension in Kazakh. Methods In this population-based association study, the genotypes of rs4149601polymorphism were identified by TaqMan PGR in 883 subjects (male 375 383 hypertensives) and its distribution and relationship to hypertension were studied. The association between haplotype ( rs4149601,296921-296923delTTG, rs2288774 and rs2288775, the last three polymorphisms are representative variations identified from 94 Kazakh hypertensive individuals by screening the functional region of NEDD4L previously) and hypertension was also investigated. Results The genotype distribution of rs4149601 polymorphism was in Hardy-Weinberg equilibrium. The genotype distribution of rs4149601 polymorphism was similar between the essential hypertension patients and the control individuals ( all P ＞ 0. 05 ). In the haplotype-based case-control analysis, the distribution of the haplotypes was not significantly different between the case and the control individuals in total and in male subjects but the frequency of D-C-G-G (296921-3delTTG/rs2288774/rs2288775/ rs4149601 )haplotype was significantly higher in hypertensive than in control individuals in female ( P = 0. 026 ). Conclusion Our results suggested that D-C-G-G hyplotype of NEDD4L but not rs4149601 polymorphism was linked with hypertension in Kazakh.
