Impact of mean fasting glucose over the first 72 hours on in-hospital outcomes of patients with ST-segment elevation myocardial infarction
10.3760/cma.j.issn.0253-3758.2010.12.004
- VernacularTitle:平均空腹血糖对ST段抬高型心肌梗死患者住院预后的影响
- Author:
Pin-Ming LIU
1
;
Fei-Ning LIN
;
Chang FANG
;
Shao-Ling ZHANG
;
Jing-Feng WANG
Author Information
1. 中山大学孙逸仙纪念医院
- Keywords:
Myocardial infarction;
Hyperglycemia;
Prognosis
- From:
Chinese Journal of Cardiology
2010;38(12):1073-1076
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the impact of mean fasting glucose over the first 72 hours after admission on in-hospital outcomes in patients with ST-segment elevation myocardial infarction ( STEMI ).Methods The data of 357 non-diabetic patients hospitalized with STEMI were collected from the database of Sun Yat-sen Memorial Hospital, affiliated to Sun Yat-sen University between January 2006 and April 2009.The patients were categorized into 3 groups according to mean fasting glucose over the first 72 hours after admission: ＜ 5.6 ( n = 165 ), 5.6 - 7.0 ( n = 122 ) and ＞ 7.0 mmol/L ( n = 70). Clinical characteristics,therapeutic approaches and the incidence of heart failure, malignant arrhythmias, and death during hospitalization were compared among groups. Multivariate logistic regression analysis was performed to determine the association between risk factors and in-hospital outcomes. Receiver-operator characteristic (ROC) curve was generated to assess the power of mean fasting glucose on predicting in-hospital death. Results Age, past history of infarction and early revascularization therapy were similar among groups. Heart rate on admission, white blood cell count, peak CK-MB level, and proportion of extensive anterior infarction were increased in proportion to higher mean fasting glucose levels. Higher mean fasting glucose levels were associated with increased risk of reduced left ventricular ejection fraction, heart failure characterized by higher Killip class, and malignant arrhythmias. After multivariate adjustment, mean fasting glucose remained to be an independent risk factor for increased in-hospital death of patients with STEMI (OR = 1.31, 95% CI: 1.10 - 1. 57;P =0. 003). Mean fasting glucose had the higher area under the ROC curve than admission glucose or fasting glucose after admission based on single measurement (0. 758, 0. 674and 0. 717;P ＜ 0. 001 ). Conclusion Mean fasting glucose during first 72 hours after admission is an independent predictor for in-hospital death and complications in patients with STEMI, which is superior to admission glucose or fasting glucose after admission based on single measurement in predicting in-hospital outcomes.
