Impact of acute glucose and fat loading on endothelium dependent vasodilation in patients with essential hypertension
10.3760/cma.j.issn.0253-3758.2010.12.008
- VernacularTitle:糖脂联合负荷对高血压患者肱动脉内皮依赖性扩张功能的影响
- Author:
Xiao-Rong ZHENG
1
;
Da-Jun CHAI
;
Feng PENG
;
Jun-Xia XU
;
Jin-Xiu LIN
Author Information
1. 福建省第二人民医院
- Keywords:
Hypertension;
Metabolism;
Endothelium,vascular
- From:
Chinese Journal of Cardiology
2010;38(12):1085-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of acute glucose and fat loading on endothelium dependent flow-mediated vasodilation (FMD) in patients with essential hypertension (EH). Methods Patients with EH were randomly divided into three groups: oral glucose loading alone (n = 26 ), oral standardized fat loading alone (n = 38), combined glucose and fat loading (n = 34 ). FMD of the brachial artery was assessed by high resolution ultrasound technique respectively. Results ( 1 ) Compared to control group, postrandial abnomal serum triglyceride metabolism was evidenced and FMD was significantly reduced and the lowest FMD occurred at 4 hours and returned to the baseline level at 8 hours post fat loading alone in EH patients. (2) GS-AUC and 1 hour glucose were significantly higher in EH patients than in controls (all P ＜0. 05), FMD was also significant decreased ( -31.4% ) at 1 hour and returned to baseline level at 2 hours post oral glucose loading. ( 3 ) After combined glucose and fat loading, FMD at 1 hour ( 5.45 ± 1.93 vs. 9.46 ± 3.33, P ＜ 0.05 ) was significantly lower than that in glucose loading alone and FMD at 4 hours ( 7. 98 ± 1. 64 vs. 9. 66 ± 2. 26, P ＜ 0. 05 ), was also lower than that in fat loading alone in EH patients.(4) FMD was negatively correlated with SBP, GS-AUC, DBP, TG-AUC ( γ= - 0. 46, - 0. 44, - 0. 41,- 0. 38,respectively, all P ＜ 0. 05 ). Conclusion Combined glucose and fat loading additively reduced FMD in hypertensive patients.
