Association between diastolic dysfunction evaluated by left ventricular flow propagation velocity and outcome in patients with hypertrophic cardiomyopathy.
- Author:
Di WU
1
;
Jun XUE
;
Yan-Qiu ZHOU
;
Wen-Jing ZHANG
;
Zheng QU
;
Da-Yi HU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; physiopathology; Cardiomyopathy, Hypertrophic; diagnostic imaging; physiopathology; Case-Control Studies; Echocardiography, Doppler, Color; Female; Heart Failure; physiopathology; Heart Ventricles; diagnostic imaging; physiopathology; Humans; Incidence; Male; Middle Aged; Risk Factors; Ventricular Function, Left; Young Adult
- From: Chinese Journal of Cardiology 2010;38(11):983-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVELeft ventricular diastolic dysfunction is common in cardiovascular diseases. Hypertrophic cardiomyopathy(HCM) is a typical disease with diastolic dysfunction. We analyzed the association between the left ventricular flow propagation velocity (FPV), quantified by color M-mode Doppler and as an indicator for diastolic dysfunction, and clinical outcome in patients with HCM.
METHODSStandard echocardiography including FPV was performed in 43 cases with HCM and 22 control cases without a clear history of heart disease. All eligible cases were followed up to more than 1 year.
RESULTSHospitalization rate due to emerging atrial fibrillation/flutter was 21%, due to emerging ventricular tachycardia was 16%, due to heart failure was 26%, and due to other events was 14% in HCM patients. FPV [(31.6 ± 11.5) cm/s vs. (68.3 ± 18.3) cm/s, P < 0.01] and FPV/E (0.49 ± 0.20 vs. 1.18 ± 0.41, P < 0.01) were significantly lower in HCM group than in control group. PV/E was an independent predictor for atrial fibrillation/flutter and heart failure, IVST was independent predictor for VT (χ(2) = 5.181, P = 0.0228), LAD (χ(2) = 6.172, P = 0.0130) and FPV/E (χ(2) = 3.932, P = 0.0474) were independent risk factors for total cardiac events.
CONCLUSIONThe incidence of atrial fibrillation and heart failure were closely related with left ventricular diastolic dysfunction in HCM patients and FPV/E was independent predictor for clinical cardiovascular events.
