Alcohol consumption and coronary heart disease in Eastern Asian men: a meta-analysis of prospective cohort studies
10.3760/cma.j.issn.0253-3758.2010.11.016
- VernacularTitle:东亚男性饮酒与冠心病的关系
- Author:
Pin-Ming LIU
1
;
Dosieah SHAILENDRASING
;
Hai-Sheng ZHENG
;
Zhi-Bin HUANG
;
Yong-Qing LIN
;
Jing-Feng WANG
Author Information
1. 中山大学孙逸仙纪念医院
- Keywords:
Alcohol drinking;
Coronary disease;
Mortality;
Meta-analysis
- From:
Chinese Journal of Cardiology
2010;38(11):1038-1044
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the dose-response relationship between alcohol consumption and relative risk of coronary heart disease (CHD) morbidity, mortality and all-cause mortality among Eastern Asian men. Methods Potential prospective cohort studies were retrieved by searching Pubmed (1966-2000), Biosis Previews (1980-2009), Embase (1980-2009) and ISI Web of Knowledge (1986-2009)using Medical Subject Headings alcohol drinking, ethanol, coronary heart (or artery) disease, myocardial infarction, mortality, etc; and Koreans,or Japanese or Chinese.From the 28 relevant retrieved reports,15 prospective cohort studies met the criteria were included.Information on study design,participant characteristics, level of alcohol consumption, CHD outcome, control for potential confounding factors, and risk estimates were abstracted using a standardized protocol.For each study, relative risks (RR) and 95% confidence intervals (CI) were extracted and pooled with either a fixed effect model or random effect model according to the result of the test of heterogeneity. Results Due to the limited available data for women,this study only comprised of 2406 cases of CHD among 177 723 male subjects.Findings were also pooled from 216 233 male subjects and 15 462 deaths from any cause. Compared with nondrinkers, the RRs on CHD morbidity for those who drank alcohol≤20, 21-40, 41-60,＞60g/d were 0.65 (0.34-1.23,P=0.18), 0.48 (0.26-0.87,P=0.02), 0.46 (0.32-0.67,P＜0.01),and 0.48(0.29-0.78,P＜0.01 ) respectively; the RRs on CHD mortality were 0. 98 (0.73-1.31 ,P=0.87), 0.68 (0.58-0.79,P＜0.01), 0.64 (0.43-0.96,P=0.03), 0.75 (0.54-1.03,P=0.08); and on all-cause mortality were 0.83 (0.79-0.91, P＜0.01), 0.93 (0.87-0.99, P=0.03), 1.01 (0.95-1.07, P=0.86),1.32 (1.29-1.36, P＜ 0.01 ). Conclusion Light-to-moderate alcohol intake was associated with decreased risk of CHD morbidity and mortality, while heavy alcohol intake was associated with increased allcause mortality among Eastern Asian men.
