Circadian blood pressure variability and plasma neopterin level before and after surgery for obstructive sleep apnea syndrome
10.3760/cma.j.issn.0253-3758.2011.02.010
- VernacularTitle:阻塞性睡眠呼吸暂停综合征患者多平面手术前后的血压昼夜节律与血清新蝶呤变化
- Author:
Hai-Ling WANG
1
;
Yun-Dai CHEN
;
Yu WANG
;
Ying ZHANG
;
Xin-Chun WANG
;
Zhi-Xuan LIU
;
Guo-Li JING
;
Hai-Feng TONG
;
Yuan TIAN
;
Ke SHI
;
Qing-Zeng LIU
Author Information
1. 北京军区总院
- Keywords:
Sleep apnea syndrome;
Neopterin;
Blood pressure
- From:
Chinese Journal of Cardiology
2011;39(2):132-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of circadian blood pressure variability (BPV) and plasma neopterin before and after surgey (uvulopalatopharyngoplasty) for patients with obstrcuctive sleep apnea syndrome (OSAS). Methods A total of 382 OSAS patients underwent uvulopalatopharyngoplasty were divided into three groups based on polysomnography (PSG) results: mild OSAS ( n = 206 ), moderate OSAS (n = 108 ) and severe OSAS (n = 68 ). Plasma neopterin, 24-hour ambulatory blood pressure monitoring (ABPM), PSG were measured before and 3 months after surgery. Results Plasma neopterin increased in proportion to severity of OSAS before surgery (15.08 nmol/L,27. 68 nmol/L and 37.32 nmol/L in patients with mild to severe OSAS) which were significantly reduced post surgery (9. 92 ng/ml, 15.07 ng/ml and 18. 54 ng/ml, all P ＜0. 05 vs. pre-surgery). The incidence of non-dipper curve in three OSAS groups were 50. 2% ,72. 7% and 86. 5%, respectively before surgery and the values decreased to 34. 8%,48. 2% and 49. 2% after surgery (all P＜0. 05 vs. pre-surgery). Relevance analysis indicates that D-value of nocturnal and diurnal blood pressure was negatively correlated with plasma neopterin. Conclusion Our findings indicated that plasma neopterin and the incidence of non-dipper could reliably reflect OSAS severity and could thus be used to evaluate the surgery efficacy. Plasma neopterin might be an important player in the pathophysiology of OSAS via modulating blood pressure variability.
