Clinical characteristics of fat replacement of left ventricular myocardium.
- Author:
Chao-wu YAN
1
;
Shi-hua ZHAO
;
Hua LI
;
Shi-liang JIANG
;
Jian LING
;
Yan ZHANG
;
Bin LÜ
;
Min-jie LU
;
Yun-qing WEI
;
Cheng CAO
;
Xiao-ou QI
;
Min-fu YANG
;
Wei FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adipocytes; cytology; Adipose Tissue; physiopathology; Adult; Aged; Female; Heart Ventricles; diagnostic imaging; physiopathology; Humans; Male; Middle Aged; Myocardial Infarction; diagnostic imaging; Myocardium; cytology; Retrospective Studies; Tomography, X-Ray Computed; Ventricular Dysfunction, Left; diagnostic imaging; physiopathology
- From: Chinese Journal of Cardiology 2011;39(2):152-155
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the clinical characteristics of left ventricular fat replacement.
METHODSWe identified 45 patients [28M/17F, mean age (51.9 ± 14.7) years] with left ventricular myocardial fat replacement (CT value ≤ -30 Hu) by cardiovascular CT.
RESULTSAmong 45 patients, 25 patients [20M/5F, mean age (61.2 ± 10.4) years]were diagnosed as coronary artery disease (CAD). There was 56%single-vessel disease, 20% double-vessel disease and 24%triple-vessel disease, true left ventricular aneurysm was detected in 3 patients and left ventricular thrombi in 1 patient, the dimension of left ventricle was (54.5 ± 9.4) mm and the LVEF was (51.8 ± 13)% in CAD group. In this group, fat replacement occurred in the region of myocardial infarction and presented as curvilinear band in subendocardial region. The left ventricular wall thickness was lower than 5 mm in 21 cases. The location of fat replacement in CAD group is as follows: apical region in 18 patients, distal septal in 15 patients, distal anterior in 11 patients, mid-septal in 7 patients, mid-anterior in 7 patients and basal in 1 patients. The age of remaining 20 patients (8M/12F) without CAD were (57.8 ± 13.3) years. In the group of non-CAD, dilated cardiomyopathy was diagnosed in 3 patients, atrial septal defect in 1 patient, rheumatic heart disease in 1 patient, there was no structural heart disease in the remaining 15 patients. The dimension of left ventricle was (51.1 ± 9.1) mm and the LVEF was (59.4 ± 13.9)%. In non-CAD group, fat replacement mainly occurred in septal region, presented as curvilinear band in 17 patients and patch in 3 patients. The location of fat replacement in this group is as follows: mid-septal region in 11 patients, distal-septal in 10 patients and apical in 9 patients. The intramural fat replacement was detected in 14 patients: subendocardial fat replacement in 10 patients and both intramural and subendocardial fat replacement in 4 patients.
CONCLUSIONSLeft ventricular fat replacement could be documented in CAD patients, non-CAD cardiomyopathy patients and in patients without structural heart disease. Left ventricular fat replacement often positioned in apical region in CAD patients as a consequence of infarct healing while mostly positioned in septal region in non-CAD patients, the definite clinical implication of left ventricular fat replacement in non-CAD patients remains to be clarified.