Time course of C4a and platelet aggregation rates in no-reflow pntients with acute myocardial infarction undergoing percutaneous coronary intervention
10.3760/cma.j.issn.0253-3758.2011.02.018
- VernacularTitle:急性心肌梗死介入术后无复流患者血清补体4a水平和血小板聚集率的变化
- Author:
Su-Xia GUO
1
;
Zhen-Yu YANG
;
Ru-Xing WANG
Author Information
1. 南京医科大学附属无锡市人民医院
- Keywords:
Complement C4a;
Platelet aggregation;
Myocardial infarction;
Angioplasty,transluminal,percutaneous coronary
- From:
Chinese Journal of Cardiology
2011;39(2):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe serum C4a and platelet aggregation rates changes in acute myocardial infarction (AMI) patients before and after percutaneous coronary intervention (PCI)and association with the development of no-reflow phenomenon. Methods From June 2006 to August 2009, 119 AMI patients underwent PCI (28 cases of no-reflow group, 91 cases of reflow group)and 30 subjects with suspected coronary heart diseases and normal coronary angiography results (control group) were enrolled in this study. C4a and platelet aggregation rate were measured at 30 minutes before PCI, immediately after PCI,30 minutes,l hour,2 hour, and 6 months post PCI in AMI patients and at before coronary angiography in control subjects. Results The levels of serum C4a at 30 minutes prior to PCI in control, no-reflow, and reflow groups were similar(P ＞0. 05). Platelet aggregation rate at 30 minutes prior to PCI was significantly higher in no-reflow group and reflow group than in control group ( all P ＜ 0. 05 ). Serum C4a and platelet aggregation rates were significantly higher in no-reflow group at immediate, 30 minutes and 1 hour after PCI than at 30 minutes prior to PCI, two hours and 6 months after PCI ( all P ＜ 0. 05), and were significantly higher than in reflow group at immediate, 30 minutes and 1 hour after PCI ( all P ＜ 0. 05 ). Serum C4a and platelet aggregation rates were similar at different time points in reflow group ( all P ＞ 0. 05 ). The levels of C4a in no-reflow group at immediate, 30 minutes and 1 hour after PCI were positively correlated with platelet aggregation rates (r=0. 91,0. 79 ,0. 60 ,respectively ,all P＜0.01). Conclusion The transient increase on levels of C4a and platelet aggregation rate early post PCI are verified in no-reflow patients with AMI undergoing PCI.
