Abnormal expression of cCD79a/cCD22 in acute myeloid leukemia with t (8;21).
- Author:
Guang-sheng HE
1
;
Ling ZHOU
;
De-pei WU
;
Yong-quan XUE
;
Ming-qing ZHU
;
Dan-dan LIU
;
Ai-ning SUN
;
Zheng-ming JIN
;
Hui-ying QIU
;
Miao MIAO
;
Xiao-wen TANG
;
Zheng-zheng FU
;
Xiao MA
;
Xiu-li WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; CD79 Antigens; metabolism; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Female; Humans; Immunophenotyping; Leukemia, Myeloid, Acute; genetics; Male; Middle Aged; Sialic Acid Binding Ig-like Lectin 2; metabolism; Translocation, Genetic; Young Adult
- From: Chinese Journal of Hematology 2006;27(3):187-189
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo report abnormal expression of cCD79a/cCD22 in four cases of acute myeloid leukemia (AML) with t (8;21).
METHODSThe characteristics of morphology, immunophenotype, chromosome karyotype (MIC) and clinical manifestations of 4 AML patients with t (8;21) expressing cCD79a/cCD22 were analyzed.
RESULTSThe features of the 4 patients were: (1) no difference in gender; (2) young age; (3) exmedullary infiltration may be present; (4) normal number of white blood cells in peripheral blood; (5) morphology showed acute myeloid leukemia with high percentage of blast cells; (6) B-lymphoid and myeloid immunophenotype, and high expression of CD34; (7) frequent depletion of Y chromosome and complex changes of chromosomes; (8) positive for AML1/ETO fusion gene; (9) response well to chemotherapy regimen which simultaneously treated myeloid and lymphocytic leukemia.
CONCLUSIONAbnormal expression of cCD79a/cCD22 in AML with t (8;21) (q22;q22) suggested that this kind of leukemia might be related with abnormal expression gene of B cell.
