Natural killer-like T-cell lymphoma/leukemia--a case report and literature review.
- Author:
Feng-kui ZHANG
1
;
Hui-jun WANG
;
Yu-hong WU
;
Shu-xu DONG
;
Hong-qiang LI
;
Dong-lin YANG
;
Hui-shu CHEN
;
Yu-lin CHU
Author Information
- Publication Type:Case Reports
- MeSH: Adolescent; CD56 Antigen; immunology; Female; Humans; Killer Cells, Natural; immunology; pathology; Leukemia, T-Cell; immunology; pathology; Lymphoma, T-Cell; immunology; pathology
- From: Chinese Journal of Hematology 2006;27(4):226-230
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.
METHODSThe characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.
RESULTSA 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.
CONCLUSIONSNatural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.
