Establishment of a comprehensive database for laryngeal cancer related genes and the miRNAs
10.3760/cma.j.ossn.1673-0860.2015.09.013
- VernacularTitle:喉癌相关基因和miRNA综合数据库的构建
- Author:
Mengjiao LI
1
;
Qimin E
;
Jialin LIU
;
Tingting HUANG
;
Chuanyu LIANG
Author Information
1. 四川大学华西医院/华西临床医学院医学信息学教研室
- Keywords:
Laryngeal neoplasms;
Neoplasm proteins;
ATP-binding cassette transporters;
MicroRNAs;
Database
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2015;50(9):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Objective By collecting and analyzing the laryngeal cancer related genes and the miRNAs,to build a comprehensive laryngeal cancer-related gene database,which differs from the current biological information database with complex and clumsy structure and focuses on the theme of gene and miRNA,and it could make the research and teaching more convenient and efficient.Methods Based on the B/S architecture,using Apache as a Web server,MySQL as coding language of database design and PHP as coding language of web design,a comprehensive database for laryngeal cancer-related genes was established,providing with the gene tables,protein tables,miRNA tables and clinical information tables of the patients with laryngeal cancer.Results The established database containsed 207 laryngeal cancer related genes,243 proteins,26 miRNAs,and their particular information such as mutations,methylations,diversified expressions,and the empirical references of laryngeal cancer relevant molecules.The database could be accessed and operated via the Internet,by which browsing and retrieval of the information were performed.The database were maintained and updated regularly.Conclusion The database for laryngeal cancer related genes is resource-integrated and user-friendly,providing a genetic information query tool for the study of laryngeal cancer.
