Matrix metalloproteinase-1 gene-519A/G polymorphism and the risk of coronary heart disease in Northern Chinese Han population
10.3321/j.issn:0253-3758.2008.03.002
- VernacularTitle:基质金属蛋白酶1基因-519A/G多态性与冠心病发病的关系
- Author:
Ya-Ling HAN
1
;
Ze-Feng WU
;
Xiao-Lin ZHANG
;
Cheng-Hui YAN
;
Yong YANG
;
Su-Ya XI
;
Jian KANG
Author Information
1. 沈阳军区总医院
- Keywords:
Coronary disease;
Matrix metalloproteinase;
Single nucleotide polymorphism
- From:
Chinese Journal of Cardiology
2008;36(3):195-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between matrix metalloproteinase(MMP)1 gene-519A/G polymorphism and the risk of coronary heart disease(CHD)in Northern Chinese Han population.Methods A total of 517 patients with CHD and 380 healthy adults diagnosed by coronary angiography were genotyped by polymerase chain reaction-restriction fragment length polymorphism and DNA sequence technology for the-519A/G polymorphism in MMP1 gene.Results (1)The frequency of AA genotype was significantly higher in patients with CHD than that in controls[67.70%(350/517) vs.40.26%(153/380),OR=1.64,P＜0.001,95%CI:1.44-1.86].People carrying A allele had increased risk for CHD(OR=1.49,P＜0.001,95% CI:1.33-1.69).(2)The frequency of AA genotype was higher in patients with acute coronary syndrome(ACS)than patients with stable angina pectoris[68.81%(278/404)vs.51.76%(44/85,),P＜0.01,95% CI:1.04-1.27].The A allele carriers were more likely to develop ACS(OR=1.11,95% CI:1.01-1.21,P＜0.05).Conclusion Our data shows MMP1 gene -519A/G polymorphism is associated with the risk of CHD,and A allele carriers are more susceptible for CHD in Northern Chinese Han population.
