Peripheral dendritic cell subpopulation changes in patients with coronary artery disease.
- Author:
Qiang FU
1
;
Zhi-Liang LI
;
Xiao LEI
;
Xiao-Hua FU
;
Quan-Neng YAN
;
Ying-Feng LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Angina, Unstable; blood; immunology; Case-Control Studies; Cell Count; Coronary Artery Disease; blood; immunology; Dendritic Cells; immunology; Humans; Middle Aged; Myocardial Infarction; blood; immunology
- From: Chinese Journal of Cardiology 2008;36(3):209-211
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the peripheral dendritic cell subpopulation changes in patients with or without coronary artery disease.
METHODSA total of 60 patients with angiographic documented coronary artery disease (CAD) were recruited in this study, including 20 cases with acute myocardial infarction (AMI group), 20 cases with unstable angina(UA group) and 20 patients with stable angina (SA group). Eleven patients with chest pain and without coronary stenosis served as chest pain control (CPS group). Ten cases without heart diseases served as normal control (Normal control group). Numbers of peripheral myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) precursors were determined by FACS.
RESULTThe proportions of mDC precursors were significantly lower in UA group and AMI group (4.7% +/- 2.6%, 5.0% +/- 2.7%) than that in SA, CPS and control groups (11.0% +/- 6.4%, 12.0% +/- 3.9%, 12.3% +/- 3.3%, respectively, all P < 0.001). pDC numbers were similar among groups.
CONCLUSIONReduced circulating mDC subsets in patients with unstable angina and AMI might suggest enhanced mDC recruitment to vulnerable plaques in these patients.
