Detection of periodontal pathogenic bacteria DNA in coronary atheromatous plaques from patients underwent coronary artery bypass graft
10.3321/j.issn:0253-3758.2008.03.007
- VernacularTitle:冠状动脉粥样硬化斑块与牙周致病菌的关系
- Author:
Yuan-Ming ZHANG
1
;
Liang-Jun ZHONG
;
Ping LIANG
;
Hua LIU
;
La-Ti MU
Author Information
1. 新疆医科大学附属第一医院
- Keywords:
Coronary atherosclerosis;
Dental plaque;
Polymerase chain reaction
- From:
Chinese Journal of Cardiology
2008;36(3):215-218
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to observe the coexistence of periodontal bacteria DNA(Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum,Porphyromonas gingivalis,Prevotella intermedia,Tannerella forsythensis)in coronary atheromatous plaques and subgingival plaques in patients scheduled for coronary artery bypass graft.Methods Coronary atheromatous plaque and subgingival plaque samples were obtained from 51 patients and examined by polymerase chain reaction (PCR)technique with specific primers for periodontal bacteria.Results P.gingivalis(33%),T.forsythensis(31%),P.intermedia(18%) and F.nucleatum (12%) were detected while A.aetinomycetemcomitans was negative and not found in coronary atheromatous plaques;T.forsythensis (84%),F.nucleatum(78%),P.intermedia(59%),P.gingivalis(39%) and A.actinomycetemcomitans (22%) were detected in subgingival plaque samples.Coexistence of periodontal bacteria DNA in coronary atheromatous and subgingival plaque samples was evidenced in 32 patients.Conclusions The coexistence of T.forsythensis,F.nucleatum,P.intermedia,P.gingivalis in coronary atheromatous plaques and the subgingival plaque samples in CAD patients could suggest a potential role for periodontal pathogenic bacteria in atherosclerosis disease process.
