Circulating cytokine measurements by protein chips in patients with acute coronary syndrome.
- Author:
Hua MAO
1
;
Ting-Zhu LIU
;
Mei WEN
;
Jing-Jing CHEN
;
Ling LI
;
Jin-Kun ZHU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Coronary Syndrome; blood; Aged; Angina Pectoris; blood; Angina, Unstable; blood; C-Reactive Protein; metabolism; CD40 Ligand; blood; Cytokines; blood; Female; Humans; Male; Matrix Metalloproteinase 9; blood; Middle Aged; Myocardial Infarction; blood; Protein Array Analysis
- From: Chinese Journal of Cardiology 2008;36(3):219-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the feasibility of measuring multiple circulating cytokines by protein chips in patients with acute coronary syndrome (ACS).
METHODSCirculating cytokines were determined by protein chips in 50 control cases and 104 ACS cases of unstable angina pectoris (UA, n = 50) and acute myocardial infarction (AMI, n = 54) cases.
RESULTSThe levels of serum MMP-9, sCD40L, CRP, IL-6, H-FABP, cTnI and plasma IL-8, NT-proBNP, sVCAM-1, ET-1 in ACS group were significantly higher than those in the control group (all P < 0.01). Serum H-FABP and cTnI were significantly higher in AMI patients than in UA patients (P < 0.01). Serum MMP-9, sCD40L, CRP, IL-6 and plasma sVCAM-1, ET-1 tended to be higher in AMI patients as compared to UA patients (all P > 0.05). Serum MMP-9, sCD40L, and H-FABP were positively correlated with the severity of angina(r = 0.653, r = 0.745, r = 0.933, P < 0.01, respectively). Serum MMP-9, sCD40L, and H-FABP increased in proportion to the levels of Braunwald angina classes in UA patients (angina class I < angina class II < angina class III, P < 0.01).
CONCLUSIONSCirculating cytokines were significantly increased in ACS patients and positively correlated to Braunwald angina classes in UA patients.
